Enzymes: Difference between revisions

From DISI
Jump to navigation Jump to search
No edit summary
 
m (1 revision)
(No difference)

Revision as of 20:17, 8 October 2012

Enzymes generally make excellent targets for small molecule ligand discovery because

  • they are pre-organized to carry out a reaction and thus have destabilizing unsatisfied residues that are available for ligand binding
  • there is often a chemical starting point available in the form of the endogenous ligand
  • there is hope that interfering with catalysis will have an effect because a bound ligand directly competes with the natrual substrate.


Back to targets.