News of 2025-09 Sep

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This is the news of September 2025.

  • we are building H30-H33 P300-350 in zinc-22c.
  • we have removed zinc-22n/H24 from Wynton to make space
  • currently is [a-m] for all tranches in all layers, except zinc-22n where H24, H25, H26 are missing
  • we are creating a new version of the 3d building pipeline that uses the Uppsala drop-in replacements for auxilliary programs.
  • we are working on natural products (more soon)

Change coming by the end of September 2025

  • to cover all tranches and layers evenly, we are changing what we load on Wynton.
  • 100% to H19.
  • 100% from H27 to H49
  • 38% from H20 to H26, evenly spread over all layers and tranches.
  • thus 100% of zinc-22?/H[01]?/H??[PM]???/[a-z]/*.db2.tgz. 100%
  • 100% of zinc-22/H2[789]/ and 100% of zinc-22/H[34]?/
  • 38% of zinc-22?/H2[0-6]/H??[PM]???/[a-j]/*.db2.tgz. 38%
  • Only on gimel: zinc-22?/H[234]?/H??[PM]???/[k-z]/*.db2.tgz. 62%.
  • Footprint on Wynton of ZINC-22: about 1.2-1.3 PB.
  • Foot print on Gimel2 of ZINC-22: about 3.3 PB. (as of Sept 19, 2025)
  • 100% of b, c (H30+)
  • 100% of bb, cc (zwitterions)
  • the macrocycles in zinc-22w have been retired to zinc-22ww (no longer part of offical ZINC-22)


This means:

  • you can dock an even representative sample of ZINC-22 on Wynton.
  • you can dock 100% of ZINC-22 up to H19.
  • if you want to dock H20 or above, you must use gimel.

Thank you for reading. Please let your IT team know of any concerns.

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