DOCK Blaster:History

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  • 1982-1993: DOCK Blaster draws heavily upon the manual docking protocol developed in Tack Kuntz's lab.
  • 1989-2000 Further refinements of the manual protocol in Brian Shoichet's lab.
  • 2000 Preliminary work by John Irwin
  • 2001 First MakeDOCK script by David M. Lorber in Brian Shoichet's lab.
  • 2001 Further refinements to MakeDOCK by Binqing Wei
  • 2002 Refinements and new contributions by Austin N. Kirschner
  • 2004-2006 Niu Huang's work on DUD was the first real test of semi-automated docking
  • 2003-06 DOCK Blaster with GUI starts to be used by members of the Shoichet Lab.
  • 2007-03 Alpha testing with 10+ users outside UCSF.
  • 2007-09 DOCK Blaster can "do DUD automatically"
  • 2007-10 Beta testing with 30+ users outside UCSF.
  • 2008 Francesco Colizzi develops "be_blasti" and "auto_dock" enabling docking from a PDB code alone.
  • 2009-01 Number of users > 50
  • 2009 Eddie Cao performs extensive testing.
  • 2009-05 Manuscript submitted
  • 2009-08 Manuscript accepted, DOCK Blaster becomes public.
  • 2009-09 Manuscript published.