Psicquic channels

Target-Target Channels (tt)

• 1. Sea prediction (T-T) (swissprot to swissprot)
• 2. blast similarity (Evalue)
• 3. co-expression data from Matt (100 to 0 percentile rank)
• 4. shared ligand, 1uM or better
• 5. PPI (biogrid, experimental)

Target-Compound Channels (ct)

• 1. Experimental binder, is bioactive and binds 1uM or better per chembl20 (chebi name to swissprot name)
• 2. is a drug and binds target 10uM or better
• 3. Is biogenic and binding 1uM or better
• 4. is and endogenous metabolite for this target
• 5. SEA prediction (TC, P-value) (chebi to swissprot)

= Compound-Compound Channels (cc)

• 1. EBI compound (chebi) to ZINC (zincid)
• 2. nearest metabolite, drug, biogenic, purchasable
• NB not supported at our client, but we can still prepare for it