Bioisosteres
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The bioisostere tool is available at n-9-38:5000 and is currently in development. When it is ready for production it will appear at bioisostere.docking.org
Table of bioisosteric replacements.
other methods
http://www.swissbioisostere.ch/ - online tool
Accompanying paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531158/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531158/pdf/gks1059.pdf