http://wiki.docking.org/index.php?action=history&feed=atom&title=Scaffold_hopping 2026-04-08T21:29:43Z Revision history for this page on the wiki MediaWiki 1.39.1 http://wiki.docking.org/index.php?title=Scaffold_hopping&diff=4320&oldid=prev 2012-10-08T20:32:23Z

<p>2 revisions</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:32, 8 October 2012</td> </tr> <!-- diff cache key wikidb:diff::1.12:old-4319:rev-4320 --> </table>

Therese http://wiki.docking.org/index.php?title=Scaffold_hopping&diff=4319&oldid=prev 2008-07-17T18:41:48Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:41, 17 July 2008</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l6">Line 6:</td> <td colspan="2" class="diff-lineno">Line 6:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>-- John Irwin</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>-- John Irwin</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Jargon]]</ins></div></td></tr> <!-- diff cache key wikidb:diff::1.12:old-4318:rev-4319 --> </table>

Frodo http://wiki.docking.org/index.php?title=Scaffold_hopping&diff=4318&oldid=prev 2008-07-17T18:41:21Z

<p>Scaffold Hopping</p> <p><b>New page</b></p><div>Scaffold hopping is the name for a group of [[ligand based]] techniques that seek to discover new ligands starting from existing ligands. There are three classes of such tools: [[Pharmacophore-based methods]], [[fingerprint based methods]] and [[shape based methods]].<br /> <br /> Scaffold hopping is much used and appreciated in the [[pharmaceutical industry]] because it is likely to suggest compounds that are similar to known actives, that have a good chance of being active themselves. In contract, [[target based]] methods such as docking tend to produce a much lower rate of actives, but the few that are active are more likely to be really different from what is already known.<br /> <br /> Most modern ligand discovery projects use some combination of [[ligand based]] and [[target based]] techniques.<br /> <br /> -- John Irwin</div>

Frodo