View source for Psicquic channels

= Target-Target Channels (tt) = 
* 1. Sea prediction (T-T) (swissprot to swissprot)
* 2. blast similarity (Evalue)
* 3. co-expression data from Matt (100 to 0 percentile rank)
* 4. shared ligand, 1uM or better
* 5. PPI (biogrid, experimental) 

= Target-Compound Channels (ct) =
* 1. Experimental binder,  is bioactive and binds 1uM or better per chembl20 (chebi name to swissprot name)
* 2. is a drug and binds target 10uM or better
* 3. Is biogenic and binding 1uM or better
* 4. is and endogenous metabolite for this target
* 5. SEA prediction  (TC, P-value) (chebi to swissprot)

= Compound-Compound Channels (cc)
* 1. EBI compound (chebi) to ZINC (zincid)
* 2. nearest metabolite, drug, biogenic, purchasable
* NB not supported at our client, but we can still prepare for it


= how to restart the server = 
* become root on zeta
* create screen and su to psicquic
* cd psicquic-solr-ws-1.3.14 (or latest)
* bash startPsicquicServerAndSolr.sh /home/psicquic/solr11  ( to start server) 
* optional: to rebuild data: bash indexMitab.sh /home/psicquic/channel2a.txt /home/psicquic/solr/






[[Category:ZINC15]]
[[Category:Psicquic]]
[[Category:Reactome]]