Regents Professor Department of Biochemistry and Molecular Biology Oklahoma State University Areas of investigation:
1) Discovery and characterization of the mechanism of action of novel inhibitors of Hsp90.
2) Determining the effect of specific co-chaperones on the client binding specificity of Hsp90.
3) Discovery of new Hsp90-dependent clients and their impact on the mechanism of Hsp90-inhibitor cytotoxicity.
4) Characterizing to impact of Hsp90 inhibitors on cancer cell proteomes to gain a better understanding of inhibitor mechanism of action.